Written By : Amitkumar Virji Maheshwari*, Bharat K. Bhoi, Bhavesh R. Sadariya, Hardik N. Javia, Jigar K. Gusani, Hariom Sharma.
Diabetes Mellitus (DM) is a group of common metabolic disorders that share the phenotype of hyperglycemia. Depending on the etiology of diabetes mellitus, factors contributing hyperglycemia include reduced insulin secretion, decreased glucose utilization, and increased glucose production. .
It has been suggested that in the diabetic patients a positive correlation between increased serum ferritin and poor glycaemic control reflected by higher HbA1c. Increased ferritin may induce diabetes through a variety of mechanisms including oxidative damage to pancreatic beta cells, impairment of hepatic insulin extraction by the liver and interference with insulin’s ability to suppress hepatic glucose production. It’s also observed that ferritin levels correlated with individual components of the metabolic syndrome particularly serum triglycerides and plasma glucose as well as markers of insulin resistance. Thus present study is designed to evaluate the correlation between serum ferritin and glycaemic control in patients of type 2 diabetes mellitus which will help to understand the significance of ferritin for the better management of type 2 diabetes mellitus.